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Updated: Jun 18, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
The role of hepcidin in iron metabolism
1David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. enemeth@mednet.ucla.edu
Abstract:
Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory.
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