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Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

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Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
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Published on: December 21, 2011

The pathophysiology of rosacea.

M A Mc Aleer1, N Lacey, F C Powell

  • 1Department of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|November 13, 2009
PubMed
Summary

Rosacea, a common skin disorder, involves factors like UV radiation, oxidative stress, and immune responses. Further research is needed to clarify its histopathology across different subtypes and lesion development.

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Area of Science:

  • Dermatology
  • Immunology
  • Pathogenesis Research

Background:

  • Rosacea is a prevalent skin condition with diverse clinical manifestations and unclear origins.
  • Etiology understanding was limited until recent translational research advancements.

Purpose of the Study:

  • To review and discuss the multifactorial pathogenesis of rosacea.
  • To highlight recent insights into the disease's development.

Main Methods:

  • Literature review of translational research on rosacea.
  • Analysis of contributing factors to rosacea pathogenesis.

Main Results:

  • Identified key pathogenic factors: UV radiation, reactive oxygen species, vascular hyperreactivity, neuropeptides, innate immune response exacerbation, microbes (H. pylori), and environmental factors (Demodex mite).
  • Recent investigations have significantly improved understanding of rosacea pathogenesis.

Conclusions:

  • Despite advances, the histopathology of rosacea requires further clarification, particularly concerning subtypes and lesion age.
  • Multifactorial etiology necessitates continued research for comprehensive understanding and treatment strategies.