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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

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The skin's barrier.

J M Jensen¹, E Proksch

¹Department of Dermatology, University Hospitals of Schleswig-Holstein, University of Kiel, Kiel, Germany. mjensen@dermatology.uni-kiel.de

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|November 13, 2009

Summary

This summary is machine-generated.

The skin

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Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

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Area of Science:

Dermatology and skin biology
Epidermal barrier function research

Background:

The skin's physical barrier, primarily in the stratum corneum (SC), prevents pathogen invasion and water loss.
It comprises protein-rich corneocytes and lipid-rich intercellular domains.
The epidermis also contributes to barrier function via cell junctions and cytoskeletal elements.

Purpose of the Study:

To review the components of the skin's physical barrier.
To explain how barrier function is regulated and altered in dermatoses.

Main Methods:

Review of scientific literature on skin barrier structure and function.
Analysis of the molecular components and regulatory mechanisms of the epidermal barrier.

Main Results:

The SC contains corneocytes with cornified envelopes and lipid-enriched extracellular layers.
Lipids like ceramides, fatty acids, and cholesterol are crucial for barrier integrity.
Filaggrin cross-links keratin, and cytokines, cAMP, and calcium regulate barrier formation.

Conclusions:

Altered lipid composition and epidermal differentiation disrupt the skin barrier.
A compromised skin barrier is implicated in atopic dermatitis, contact dermatitis, ichthyosis, and psoriasis.
Understanding barrier function is key to addressing various skin diseases.