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Updated: Jun 18, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Italian guidelines and therapeutic algorithm for actinic keratoses.

R Rossi¹, P G Calzavara-Pinton, A Giannetti

¹Section of Dermatology II, University of Florence, Local Health Unit 10, Florence, Italy. rossidermatologo@tiscali.it

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|November 13, 2009

Summary

Actinic keratosis (AK), a precursor to squamous cell carcinoma, is increasing globally. Early diagnosis and treatment, including addressing surrounding cancerous fields, are crucial for effective management and prevention.

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Last Updated: Jun 18, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Oncology
Preventive Medicine

Background:

Rising global prevalence of actinic keratosis (AK) necessitates enhanced diagnostic and preventive strategies.
AK is increasingly recognized as an in situ squamous cell carcinoma, requiring prompt therapeutic intervention.

Purpose of the Study:

To review current literature on actinic keratosis (AK) treatment modalities.
To propose clinical guidelines for the diagnosis and management of AK and field cancerization.
To integrate evidence-based findings with clinical experience for optimal patient care.

Main Methods:

Comprehensive literature review of key articles on actinic keratosis (AK) treatment.
Analysis of recent evidence regarding therapeutic alternatives for AK.
Incorporation of clinical experience and practical evaluations into guideline development.

Main Results:

Actinic keratosis (AK) management should encompass both visible lesions and the surrounding field of cancerization.
Treatment strategies must consider the underlying genetic alterations in photodamaged skin.
Approved therapeutic alternatives are available for managing AK as an in situ squamous cell carcinoma.

Conclusions:

Optimal management of actinic keratosis (AK) involves treating individual lesions and addressing field cancerization.
Clinicians should adopt a proactive approach, considering AK as an early-stage cancer.
Ongoing oncologic research may refine current treatment guidelines and therapeutic options.