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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

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Apraxia in progressive nonfluent aphasia.

Jonathan Daniel Rohrer¹, Martin N Rossor, Jason D Warren

¹Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.

Journal of Neurology

|November 13, 2009

Summary

This study investigated apraxias in progressive nonfluent aphasia (PNFA), finding distinct neuroanatomical bases for speech, orofacial, and limb apraxias. These findings highlight the clinical and anatomical separability of apraxias in PNFA patients.

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Area of Science:

Neuroscience
Neurology
Speech-Language Pathology

Background:

The relationship between specific apraxias and neurodegeneration is unclear.
Progressive nonfluent aphasia (PNFA) is linked to various apraxias and parkinsonism.

Purpose of the Study:

To identify the clinical and neuroanatomical correlates of apraxias in patients with PNFA.
To determine if different types of apraxia (speech, orofacial, limb) have distinct brain bases within PNFA.

Main Methods:

Studied 16 patients with PNFA, including those with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP).
Assessed speech, orofacial, and limb praxis using the Apraxia Battery for Adults-2.
Conducted voxel-based morphometry (VBM) on MRI scans to correlate atrophy with apraxia severity.

Main Results:

All patients had apraxia of speech (AOS); 69% had orofacial apraxia, and 44% had limb apraxia.
AOS correlated with left posterior inferior frontal lobe atrophy.
Orofacial apraxia linked to left frontal/premotor atrophy; limb apraxia to left inferior parietal lobe atrophy.

Conclusions:

Apraxias are common in PNFA and are clinically and anatomically dissociable.
Distinct brain regions underpin different apraxias in PNFA, informing diagnosis and treatment.
Findings advance understanding of neurodegenerative disease and motor control deficits.