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Published on: December 7, 2012
Feasibility and safety of triple dose platelet collection by apheresis
1Munich Blood Bank, Munich, Germany. rainer.moog@muenchener-blutbank.de
Background:
Blood cell separators of the newest generation allow for the collection of high-dose platelet concentrates. The aim of this study was to evaluate triple dose platelet collection with respect to feasibility and safety.
Materials And Methods:
Four hundred eighty plateletphereses were performed targeting to collect a triple platelet dose. Platelet counts were performed before and after apheresis and in platelet concentrates. Furthermore, donors were monitored for adverse events.
Results:
Triple dose platelet collection was achieved in 96% according to European and national guidelines. Mean donor platelet count before apheresis was 303 +/- 64/nl and decreased to 195 +/- 48/nl after plateletpheresis. The lowest platelet count after apheresis was 111/nl. Twenty-one donor adverse events were observed (4.4%).
Conclusions:
Triple dose platelet collection is feasible and safe provided that donors are carefully checked for triple dose eligibility.
