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Phenylalanine sensing based on surface plasmon resonance.

Hongxia Chen¹, Jaebeom Lee, Sung-Hoon Kim

¹College of Nanoscience and Nanotechnology, Pusan National University, Pusan 609-735, Korea.

Journal of Nanoscience and Nanotechnology

|November 14, 2009

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This study developed a phenylalanine sensor using photochromic spiroxazine and surface plasmon resonance (SPR). The sensor differentiates between d- and l-phenylalanine based on their interaction with the spiroxazine monolayer.

Area of Science:

Analytical Chemistry
Materials Science
Biochemistry

Background:

Developing selective sensors for chiral molecules like phenylalanine is crucial.
Surface plasmon resonance (SPR) offers high sensitivity for molecular interactions.
Photochromic spiroxazine derivatives can be functionalized for molecular recognition.

Purpose of the Study:

To construct a phenylalanine sensing system utilizing a photochromic spiroxazine derivative.
To investigate the interaction between d- and l-phenylalanine enantiomers and a spiroxazine monolayer.
To assess the stability and potential applications of the developed sensor.

Main Methods:

Fabrication of a recognition-functional spiroxazine monolayer on a gold surface via self-assembly.

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Characterization of the monolayer using spectroscopic techniques.

Analysis of d- and l-phenylalanine interactions using surface plasmon resonance (SPR).

Confirmation of experimental results using computational simulations (Molecular Orbital PACkage AM1).

Main Results:

A stable spiroxazine monolayer was successfully formed on the gold surface.
Distinct SPR angle shifts were observed for d- and l-phenylalanine, attributed to differences in dipole moments of ionic complexes.
The spiroxazine monolayer demonstrated long-time stability under repeated UV-induced switching.

Conclusions:

The developed SPR-based system effectively distinguishes between d- and l-phenylalanine.
The sensor shows potential for simple analysis of interactions between zwitterionic molecules and analytes.
The study highlights the utility of photochromic spiroxazine derivatives in chiral sensing applications.