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Updated: Jun 18, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
Clotting, immune system, and venous thrombosis in lung adenocarcinoma patients: a prospective study
Ernesto de Meis1, Vera R Pinheiro, Mauro M Zamboni
1Clinical Pathology, Instituto Nacional do Câncer, Praça Cruz Vermelha 23, Centro, Rio de Janeiro, 20230-130, Brazil. edemeisrio@yahoo.com
Abstract:
Thrombosis is highly prevalent in cancer patients, being accepted as a bad prognosis marker. The importance of various mechanisms involved in the thrombophilic state of lung cancer patients is not well understood. In this prospective study, involving 109 unselected patients with lung adenocarcinoma, thrombosis was present in 24% of patients and affected survival in a bivariable model. However, in a multivariable evaluation, considering all the factors under study, only LAC and IgM anti-beta(2) GP I modified thrombosis risk, whereas in a Kaplan-Meyer regression model, thrombosis, IL-6, LAC, factor VIII, and IgM anti-beta(2) GP I interfered with patient's survival.
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