Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

What is Gene Expression?

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...

What is Gene Expression?

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...

Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

Parkinson Disease ll: Pathophysiology

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Translon: a single term for translated regions.

Nature methods·2025

Same author

Chuanxiong-Danggui herb pair alleviated cognitive deficits of APP/PS1 mice by promoting mitophagy.

Journal of ethnopharmacology·2025

Same author

APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence.

Nature communications·2025

Same author

APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence.

bioRxiv : the preprint server for biology·2025

Same author

Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease reveal shared and tissue-specific effects.

bioRxiv : the preprint server for biology·2024

Same author

Bicycling for Rehabilitation of Persons With Parkinson Disease: A Scoping Review.

Journal of neurologic physical therapy : JNPT·2024

Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026

Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026

Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026

Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026

Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026

Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

Gene expression in neuronal disease.

Ian C Wood¹, Nicola K Gray, Lesley Jones

¹Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

Biochemical Society Transactions

|November 14, 2009

Summary

This summary is machine-generated.

Understanding gene expression in the brain is crucial for treating neuronal diseases. Experts convened to discuss the complete DNA-to-protein pathway, advancing knowledge of brain gene regulation mechanisms.

More Related Videos

Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue

Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue

Published on: May 28, 2015

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

Related Experiment Videos

Last Updated: Jun 18, 2026

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue

Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue

Published on: May 28, 2015

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

The brain exhibits remarkable cell diversity and expresses a vast number of genes.
Dysregulated gene expression in brain cells is implicated in numerous neuronal diseases.
Current research often focuses on isolated steps of gene expression, limiting a holistic understanding.

Purpose of the Study:

To consolidate current knowledge on gene expression mechanisms in the brain.
To explore the complete pathway from DNA to protein in neuronal contexts.
To foster a comprehensive understanding of gene expression in neuronal disease.

Main Methods:

Convening experts in gene expression at the Gene Expression in Neuronal Disease meeting.
Synthesizing insights from talks and related publications presented at the forum.
Reviewing research covering transcription, RNA processing, and translation in the brain.

Main Results:

The meeting highlighted recent advancements across various stages of gene expression in neuronal cells.
A comprehensive overview of the gene expression pathway, from DNA to protein, was presented.
Discussions emphasized the complexity and multifaceted nature of gene regulation in the brain.

Conclusions:

A holistic approach is necessary to fully understand gene expression in the brain.
Further research into the complete gene expression pathway is vital for addressing neuronal diseases.
This collective knowledge provides a foundation for future investigations into brain-specific gene regulation.