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Related Concept Videos

Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

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Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
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Major types that are helpful drug targets include:

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RDL receptors.

Ian McGonigle1, Sarah C R Lummis

  • 1Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.

Biochemical Society Transactions
|November 14, 2009
PubMed
Summary
This summary is machine-generated.

Insect RDL receptors, activated by GABA, are crucial for inhibitory neurotransmission and represent a key target for insecticides due to their role in the insect central nervous system.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Entomology

Background:

  • RDL receptors are invertebrate Cys-loop ligand-gated ion channels.
  • They are GABA-activated and chloride-selective, similar to vertebrate GABA(A) receptors.
  • RDL receptors are vital for inhibitory neurotransmission in the insect central nervous system.

Purpose of the Study:

  • To highlight the significance of RDL receptors as an insecticidal target.
  • To provide an overview of RDL receptors within the context of Cys-loop channels.

Main Methods:

  • Literature review of RDL receptor function and structure.
  • Comparative analysis with related ion channels (GABA(A), glycine, nicotinic acetylcholine, 5-HT(3)).

Main Results:

  • RDL receptors are widely distributed in the insect CNS.
  • Their role in inhibitory neurotransmission is well-established.
  • These receptors are closely related to vertebrate orthologues and other Cys-loop receptors.

Conclusions:

  • RDL receptors are a primary target for insecticide development.
  • Understanding these receptors is key to advancing pest control strategies.