Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rodent ischemic stroke models and their relevance in preclinical research.

Neuroprotection (Chichester, England)·2025
Same author

Post-stroke cognitive impairment and brain hemorrhage are augmented in hypertensive mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2024
Same author

Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice.

Human molecular genetics·2024
Same author

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI).

Neuroprotection (Chichester, England)·2024
Same author

Control intervention design for preclinical and clinical trials: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable.

Neurorehabilitation and neural repair·2023
Same author

Control intervention design for preclinical and clinical trials: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable.

International journal of stroke : official journal of the International Stroke Society·2023

Related Experiment Video

Updated: Jun 18, 2026

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

Cortical excitability and post-stroke recovery.

Andrew N Clarkson1, S Tomas Carmichael

  • 1Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. anclarkson@ucla.edu

Biochemical Society Transactions
|November 14, 2009
PubMed
Summary

Stroke recovery involves brain repair through neural plasticity. Enhancing neuronal firing after stroke may promote structural changes and functional recovery, aiding neural repair.

Area of Science:

  • Neuroscience
  • Neurology
  • Cellular Biology

Background:

  • Stroke is a primary cause of adult disability.
  • The brain exhibits limited neural repair post-stroke, including functional re-mapping and new neural connections.
  • Cortical map changes and axonal alterations depend on patterned neuronal activity.

Purpose of the Study:

  • To investigate the role of neuronal excitability in post-stroke neural repair and recovery.
  • To explore how increased neuronal firing influences structural changes and cortical map alterations.

Main Methods:

  • Analysis of recent studies on neural repair mechanisms after stroke.
  • Examination of the relationship between neuronal activity and structural/functional brain changes.
  • Review of cellular processes involved in altering neuronal response to inputs.

More Related Videos

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Related Experiment Videos

Last Updated: Jun 18, 2026

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Main Results:

  • Neural repair and recovery post-stroke involve neuronal sprouting and cortical re-mapping.
  • Changes in cortical maps and axonal structures are contingent upon patterned neuronal activity.
  • Increased neuronal firing to specific inputs can induce structural changes and cortical map alterations.

Conclusions:

  • Altered neuronal excitability is a central cellular process in post-stroke neural repair.
  • Manipulating neuronal firing may be a key strategy to enhance brain repair and functional recovery after stroke.