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Published on: September 26, 2018
Underutilisation of cardiovascular medications among at-risk individuals
S J Lewis1, J G Robinson, K M Fox
1Northwest Cardiovascular Institute, Portland, OR, USA.
Insights
Many individuals at risk for cardiovascular disease (CVD) and those experiencing new CVD events do not receive recommended therapies. Adherence to guideline-recommended antihypertensive, lipid-lowering, and antiplatelet treatments remains suboptimal.
Area of Science:
- Cardiovascular Medicine
- Public Health
- Pharmacotherapy
Background:
- Cardiovascular disease (CVD) prevention guidelines recommend antihypertensive, lipid-lowering, and antiplatelet therapies.
- Assessing the utilization of these therapies in at-risk populations is crucial for guideline adherence.
- The SHIELD study provides insights into CVD therapy use among diverse risk groups.
Purpose of the Study:
- To evaluate the utilization of cardiovascular therapies in individuals at risk for CVD.
- To assess adherence to recommended antihypertensive, lipid-lowering, and antiplatelet treatments.
- To identify gaps in CVD preventive therapy prescription.
Main Methods:
- The SHIELD study classified respondents into National Cholesterol Education Program Adult Treatment Panel III risk categories: high, moderate, and low.
- Analysis included individuals with prior CVD events, new CVD events during follow-up, and type 2 diabetes mellitus.
- Proportions of respondents receiving lipid-lowering, antiplatelet, or antihypertensive agents were calculated.
Main Results:
- Lipid-lowering therapy use was low (<= 25%) across all risk groups.
- Antithrombotic therapy use was minimal, even among those with prior CVD events.
- Over 50% of at-risk individuals and over 33% of those with new CVD events were not on recommended CVD therapies.
Conclusions:
- A significant proportion of at-risk individuals and those with new CVD events are undertreated.
- Suboptimal utilization of guideline-recommended CVD therapies highlights a critical gap in preventive care.
- Further interventions are needed to improve adherence to CVD prevention guidelines.
Aims:
Guidelines recommend antihypertensive, lipid-lowering and/or antiplatelet therapy for prevention of cardiovascular disease (CVD). This study examined the utilisation of cardiovascular therapies among individuals at CVD risk to assess adherence to guidelines.
Methods:
Respondents to the SHIELD study were classified based on National Cholesterol Education Program Adult Treatment Panel III risk categories. High coronary heart disease (CHD) risk (n = 7510) was defined as self-reported diagnosis of heart disease/heart attack, narrow or blocked arteries, stroke or diabetes; moderate risk (n = 4823) included respondents with > or = 2 risk factors (i.e., men > 45 years, women > 55 years, hypertension, low high-density lipoprotein cholesterol, smoking and family history of CHD); and low risk (n = 5307) was 0-1 risk factor. Respondents reporting a myocardial infarction, stroke or revascularisation at baseline (prior CVD event) (n = 3777), those reporting a new CVD event during 2 years of follow up (n = 953), and those with type 2 diabetes mellitus (n = 3937) were evaluated. The proportion of respondents reporting treatment with lipid-lowering, antiplatelet or antihypertensive agents was calculated.
Results:
Utilisation of lipid-lowering therapy was low (< or = 25%) in each group. Prescription antithrombotic therapy was minimal among respondents with prior CVD events, but 47% received antihypertensive medication. No use before or after a new CVD event was reported by 36% of respondents for lipid-lowering, 32% for antithrombotic and > 50% for antihypertensive medications.
Conclusions:
More than 50% of at-risk respondents and > 33% of respondents with new CVD events were not taking CVD therapy as recommended by guidelines.
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