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Characteristics of apolipoprotein M and its relation to atherosclerosis and diabetes

Yan-Wei Hu1, Lei Zheng, Qian Wang

  • 1Laboratory Medicine Center, Nangfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.

Biochimica Et Biophysica Acta
|November 14, 2009
PubMed

Insights

Apolipoprotein M (apoM) is a lipocalin protein with roles in lipoprotein metabolism. Reduced apoM levels are linked to diabetes and atherosclerosis, warranting further investigation into its complex effects.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Apolipoprotein M (apoM) is a lipocalin protein superfamily member.
  • The apoM gene is primarily expressed in the liver and kidney.
  • apoM expression is regulated by transcription factors, hormones, and cytokines.

Purpose of the Study:

  • To review current understanding of apoM structure, distribution, and regulation.
  • To explore apoM's role in lipoprotein metabolism.
  • To examine apoM's association with diabetes and atherosclerosis.

Main Methods:

  • Literature review of existing studies on Apolipoprotein M.
  • Analysis of apoM's regulatory mechanisms.
  • Synthesis of data on apoM's involvement in metabolic diseases.

Main Results:

  • apoM exhibits a complex, paradoxical effect on atherosclerosis.
  • Reduced apoM expression is observed in some diabetic patients.
  • apoM is implicated in lipoprotein metabolism.

Conclusions:

  • Further research is needed to fully elucidate apoM's function.
  • apoM may serve as a potential biomarker or therapeutic target.
  • Understanding apoM's role is crucial for managing diabetes and atherosclerosis.

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