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Updated: Jun 18, 2026

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

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Published on: June 20, 2018

Technical advances in rhinologic basic science research.

Murugappan Ramanathan¹, Justin H Turner, Andrew P Lane

¹Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine, Johns Hopkins Outpatient Center, 6th Floor, 601 N. Caroline Street, Baltimore, MD 21287, USA.

Otolaryngologic Clinics of North America

|November 14, 2009

Summary

This summary is machine-generated.

Chronic rhinosinusitis (CRS), a common condition, needs better understanding. This review covers new technologies like real-time PCR and genomics to explore CRS pathophysiology and improve treatment.

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Area of Science:

Rhinology
Immunology
Genetics

Background:

Chronic rhinosinusitis (CRS) is a prevalent condition affecting 16% of US adults.
Current understanding of CRS pathophysiology remains incomplete.
Technological advancements offer new avenues for research.

Purpose of the Study:

To review recent technological advancements in rhinology.
To describe methodologies contributing to CRS understanding.
To highlight the role of new technologies in advancing CRS research.

Main Methods:

Real-time polymerase chain reaction (PCR)
Epithelial cell culture
Flow cytometry
Genomics and single-nucleotide polymorphism (SNP) detection
Microarrays
Genetic and non-genetic animal models of sinusitis

Main Results:

These technologies provide novel tools for investigating CRS.
Methodologies enable deeper insights into cellular and genetic aspects of CRS.
Animal models facilitate the study of sinusitis mechanisms.

Conclusions:

Technological progress is crucial for advancing CRS knowledge.
New methods enhance the study of CRS pathophysiology.
Further application of these technologies will improve understanding and management of CRS.