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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
A new approach to interventional atrioventricular valve therapy
Andreas Goetzenich1, Guido Dohmen, Nima Hatam
1Clinic for Cardiothoracic and Vascular Surgery, University Hospital RWTH Aachen, Aachen, Germany.
The Journal of Thoracic and Cardiovascular Surgery
|November 14, 2009
Summary
A novel approach successfully anchored a new biologic heart valve in the mitral position using a self-expanding hollow body. This method effectively treated mitral regurgitation in an animal model, offering a feasible alternative for valve implantation.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Interventional Cardiology
Background:
- Transcatheter mitral valve interventions for mitral regurgitation present significant technical challenges.
- Existing methods often require direct manipulation of the native valve structure.
Purpose of the Study:
- To investigate a novel approach for anchoring a biologic heart valve in the mitral position using a self-expanding hollow body.
- To assess the feasibility and efficacy of this new method in a simulation and an animal model.
Main Methods:
- A custom nitinol and polyvinylidene fluoride device was created to house a stentless biologic valve.
- The device was tested in a simulator and subsequently implanted in 8 pigs with induced mitral regurgitation under extracorporeal circulation.
- Hemodynamic, echocardiographic, radiologic, and postmortem examinations were performed.
Main Results:
- The self-expanding hollow body successfully anchored the biologic valve in the mitral position, adapting to surrounding structures.
- The device effectively excluded the left atrium and demonstrated sufficient treatment of mitral regurgitation, confirmed hemodynamically and echocardiographically.
- Postmortem examination revealed proper device positioning without significant trauma to adjacent cardiac structures.
Conclusions:
- Mitral valve anchoring can be achieved without direct manipulation of the native heart valve structure.
- This novel approach of placing a valve-carrying hollow body in the mitral position is feasible and effective for treating mitral regurgitation.
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