Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 18, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

Interfraction and intrafraction setup variability for prone breast radiation therapy.

James Mitchell1, Silvia C Formenti, J Keith DeWyngaert

  • 1Department of Radiation Oncology, New York University School of Medicine, New York, NY 10016, USA.

International Journal of Radiation Oncology, Biology, Physics
|November 14, 2009
PubMed
Summary

This study quantifies setup variations in prone breast radiotherapy, establishing a 1.4 cm clinical tumor volume (CTV) to planning target volume (PTV) margin for accurate treatment delivery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iterative Multidisciplinary Development and Evaluation of a Patient-Facing SDoH Chatbot Using Synthetic Data Simulation.

JMIR formative research·2026
Same author

Determining Optimal Fractionation of Neoadjuvant Radiation in Low-Risk, Early-Stage Breast Cancer-Randomized SIGNAL Clinical Trial.

Cancers·2026
Same author

Radiation Oncology-Biology Integration Network: Bridging the Gap between Biological Research and Clinical Practice.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Oral Islatravir in Macaques Decreases Lymphocytes and Monocytes and Is Associated with Immune Alterations.

Pharmaceutics·2026
Same author

Barriers and facilitators to implementing a shared decision-making tool for anticoagulant-related drug-drug interactions: a qualitative study across three academic medical centres in the USA.

BMJ open·2026
Same author

Small bowel obstruction and frailty: a systematic review.

European geriatric medicine·2026

Area of Science:

  • Radiation Oncology
  • Medical Physics

Background:

  • Prone breast radiotherapy is utilized to minimize dose to organs at risk.
  • Accurate patient setup and motion management are crucial for effective radiotherapy.
  • Establishing appropriate margins between clinical tumor volume (CTV) and planning target volume (PTV) is essential to account for uncertainties.

Purpose of the Study:

  • To quantify interfraction and intrafraction setup variations in patients undergoing prone breast radiotherapy.
  • To determine an optimal clinical tumor volume (CTV) to planning target volume (PTV) margin that accounts for setup and motion uncertainties.

Main Methods:

  • Ten patients undergoing accelerated, hypofractionated prone breast irradiation were prospectively studied.
  • Electronic portal imaging device in cine mode was used to acquire portal images.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Related Experiment Videos

Last Updated: Jun 18, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

  • Interfraction setup error was assessed by comparing daily fractions to a reference image; intrafraction motion was evaluated by measuring displacements of external fiducials and breast surface throughout each fraction.

    • Main Results:

    • Mean interfraction setup variability for fiducials was 0.08 cm (AP) and -0.04 cm (SI).
    • Mean interfraction breast surface variability was -0.14 cm (AP).
    • Mean intrafraction displacements for fiducials and breast surface were 0.13 cm and 0.15 cm, respectively. A CTV to PTV expansion of 1.4 cm was calculated.

    Conclusions:

    • Interfraction and intrafraction setup variations in prone breast radiotherapy were found to be acceptable.
    • A clinical tumor volume (CTV) to planning target volume (PTV) expansion of 1.4 cm is recommended based on the observed setup uncertainties.