Related Experiment Video
Updated: Jun 18, 2026

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
Published on: October 11, 2019
Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates
Sunny Manohar1, Shabana I Khan, Diwan S Rawat
1Department of Chemistry, University of Delhi, Delhi 110 007, India.
Abstract:
A series of 4-aminoquinoline-triazine conjugates with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum. Compounds 16, 19, 28 and 35 exhibited promising antimalarial activity against both strains of P. falciparum. Cytotoxicity of these compounds was tested against three cell lines. Several compounds did not show any cytotoxicity up to a high concentration (48microM), others exhibited mild toxicities but selective index for antimalarial activity was high for most of these conjugates.
Related Concept Videos
Antiprotozoal Agents
Anthelminthic Agents
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Inhibitors of Bacterial DNA Synthesis
Physical Properties of Amines
