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Related Experiment Video

Updated: Jun 18, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Published on: February 2, 2024

Prosthetic joint infections: single versus combination therapy.

J R Samuel¹, F K Gould

¹Department of Microbiology, Freeman Hospital, Newcastle upon Tyne, UK. julie.samuel@nuth.nhs.uk

The Journal of Antimicrobial Chemotherapy

|November 14, 2009

Summary

Treating prosthetic joint infections with antibiotics is challenging. This review examines antimicrobial monotherapy versus combination therapy, highlighting the need for comparative studies to guide treatment decisions for bone and joint infections.

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Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

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Published on: December 3, 2017

Area of Science:

Orthopedics
Infectious Diseases
Pharmacology

Background:

Prosthetic joint replacement is a common procedure to manage joint pain and improve mobility.
Bone and joint infections following prosthetic surgery present significant therapeutic challenges.
Effective antimicrobial strategies are crucial for eradicating infections associated with prosthetic joints.

Purpose of the Study:

To evaluate the efficacy of antimicrobial monotherapy versus combination therapy for prosthetic joint infections.
To synthesize findings from in vitro and in vivo studies on antimicrobial treatments.
To identify gaps in current research regarding comparative effectiveness.

Main Methods:

Systematic review of in vitro and in vivo studies.
Evaluation of various antimicrobial agents used as single agents or in combination.
Analysis of treatment outcomes for prosthetic joint infections.

Main Results:

Antimicrobial agents are essential in managing prosthetic joint infections.
The comparative effectiveness of monotherapy versus combination therapy requires further investigation.
Paucity of well-defined comparative studies exists.

Conclusions:

Optimizing antimicrobial therapy for prosthetic joint infections remains an ongoing challenge.
Further research, particularly comparative studies, is needed to establish definitive treatment guidelines.
Evidence synthesis is crucial for informed clinical decision-making in prosthetic joint infections.