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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
Published on: September 20, 2015
Hypoperfusion and ischemia in cerebral amyloid angiopathy documented by 99mTc-ECD brain perfusion SPECT
Yong-An Chung1, Joo Hyun O, Jee-Young Kim
1Department of Radiology, College of Medicine, Catholic University of Korea, Seoul, South Korea.
Insights
Cerebral amyloid angiopathy (CAA) patients exhibit reduced cerebral blood flow, particularly in the parietal and temporal lobes. This hypoperfusion may increase the risk of leukoencephalopathy, atrophy, and ischemia in individuals with CAA.
Area of Science:
- Neurology
- Radiology
- Nuclear Medicine
Background:
- Cerebral amyloid angiopathy (CAA) is a significant cause of intracranial hemorrhage in older adults.
- CAA can also lead to leukoencephalopathy, brain atrophy, and ischemia due to hypoperfusion.
- Verifying cerebral hypoperfusion in CAA patients is crucial for understanding disease progression.
Purpose of the Study:
- To investigate and confirm cerebral hypoperfusion in patients diagnosed with probable CAA.
- To utilize (99m)Tc-ethylcysteinate dimer ((99m)Tc-ECD) brain perfusion SPECT for assessing cerebral blood flow.
Main Methods:
- Included 11 patients with probable CAA and 13 age-matched healthy controls.
- Performed (99m)Tc-ECD brain perfusion SPECT on all participants.
- Analyzed and compared relative regional cerebral blood flow values between patients and controls using specialized software.
Main Results:
- Patients with probable CAA demonstrated significant hypoperfusion compared to controls.
- Specific areas of hypoperfusion included the inferior parietal lobules, middle and inferior temporal gyri, and caudate bodies.
- Statistical analysis revealed significant differences in perfusion in Brodmann areas 40, 39, 22, 10, and 20.
Conclusions:
- Patients with probable CAA exhibit significantly decreased cerebral perfusion.
- The observed hypoperfusion suggests an elevated risk for developing leukoencephalopathy, brain atrophy, and ischemic events.
- Brain perfusion SPECT with (99m)Tc-ECD is a valuable tool for detecting hypoperfusion in CAA.
Unlabelled:
Cerebral amyloid angiopathy (CAA) is known to be an important cause of spontaneous cortical-subcortical intracranial hemorrhage in normotensive older persons. CAA can also manifest as leukoencephalopathy, brain atrophy, and ischemia secondary to hypoperfusion. Our goal was to verify cerebral hypoperfusion in patients with CAA using (99m)Tc-ethylcysteinate dimer ((99m)Tc-ECD) brain perfusion SPECT.
Methods:
A total of 11 patients (5 men and 6 women; age range, 58-78 y; mean age +/- SD, 70.0 +/- 7.0 y) with clinically and radiologically established probable CAA who underwent (99m)Tc-ECD SPECT were included. (99m)Tc-ECD SPECT scans were also obtained from 13 age-matched healthy control subjects (7 men and 6 women; age range, 60-79 y; mean age +/- SD, 66.7 +/- 6.4 y) for comparison. The relative regional cerebral blood flow values obtained for patients and controls were compared using software.
Results:
Compared with controls, patients with probable CAA showed hypoperfusion in the inferior parietal lobule of both parietal lobes (Brodmann area [BA] 40), middle temporal gyrus of the left temporal lobe (BA 39), postcentral gyrus of the right parietal lobe, superior temporal gyrus of the right temporal lobe (BA 22), superior temporal gyrus of the right frontal lobe (BA 10), inferior temporal gyrus of the left temporal lobe (BA 20), and both caudate bodies (P < 0.0001, t = 4.65).
Conclusion:
Patients with probable CAA had significantly decreased cerebral perfusion and may be at risk for leukoencephalopathy, atrophy, and ischemia.
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