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Updated: Jun 18, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Allograft tissue in ACL reconstruction
David A McGuire1, Stephen D Hendricks
1University of Alaska Anchorage, Anchorage, AK, USA.
Abstract:
Musculoskeletal allografts are an essential component for the surgical management of orthopedic injuries. Allografts are most frequently used in the knee for anterior cruciate ligament (ACL) deficiency and less frequently for other ligament lesions, meniscal transplant, and osteochondral repair. Clinical ACL outcomes have continued to improve as techniques and instrumentation have developed. Allografts are routinely used for ACL reconstructions and although some may argue against them, others feel that not using allografts is a disservice to their patients. The increase in demand for a larger and safer supply of allografts is directly related to the growth in the number of allografts being used. Allografts are safe, reliable, and when all factors are considered, is an excellent ligament replacement solution surgeons should consider for their ACL patients.
