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Related Experiment Video

Updated: Jun 18, 2026

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

A Multicentre Database for Normative Brainstem Auditory Evoked Potentials (BAEPs) in Children: Methodology for Data

Vidmer Scaioli1, Mario Brinciotti, Matteo Di Capua

  • 1Fondazione IRCCS Istituto Nazionale Neurologico C. Besta, Milan.

The Open Neurology Journal
|November 14, 2009
PubMed
Summary

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Collecting brainstem auditory evoked potentials (BAEPs) data in children is feasible for clinical diagnosis. Normalizing BAEPs using the natural logarithm of age provides reliable results across multiple centers.

Area of Science:

  • Neuroscience
  • Audiology
  • Pediatrics

Background:

  • Physiological and methodological factors significantly impact brainstem auditory evoked potentials (BAEPs) recordings in children more than adults.
  • Establishing normative BAEP data in pediatric populations is crucial due to developmental variations.

Purpose of the Study:

  • To collect and evaluate brainstem auditory evoked potentials (BAEPs) data in normal children.
  • To measure intra- and inter-laboratory variability in BAEP recordings.
  • To assess the feasibility of creating a multicenter database for clinical diagnosis and research.

Main Methods:

  • Seven hundred and fifty unselected BAEP recordings were collected from children aged neonates to 14 years.
  • Data were evaluated across eight laboratories in Italy.
Keywords:
BAEPsauditory evoked potentials.brainstemchildrenmaturationnormative data

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  • Statistical analysis was performed to assess variability, age-related changes, and the impact of sound intensity and sex.

    • Main Results:

    • Newborn BAEPs showed variability, with wave I more broadly distributed than wave V and interpeak latency I-V.
    • Pooled data from older children yielded overlapping results when age-matched but significant differences when unmatched.
    • Sound intensity and sex did not significantly affect latencies; a single exponential regression model adequately predicted normal data.

    Conclusions:

    • Pooled BAEP data align with the physiological maturation of the brainstem acoustic pathway.
    • Brainstem auditory evoked potentials (BAEPs) can be reliably normalized using the natural logarithm of age.
    • Multicenter common databases are feasible and reliable for clinical diagnosis and research, with inter-center differences attributed to sample size and criteria.