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Published on: April 18, 2013
Chest computed tomography findings in familial dysautonomia patients: a model for aspiration
Nurith Hiller1, Natalia Simanovsky, Chaya Bahagon
1Department of Radiology, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel.
Background:
Lung disease in patients with familia dysautonomia is caused mainly by recurrent aspiration of gastric contents, food and liquids swallowed incorrectly.
Objective:
To describe chest computed tomography findings in patients with familial dysautonomia.
Methods:
A retrospective analysis of chest CT findings was performed for 34 FD patients (15 females, 19 males) with a mean age of 18 +/- 12.8 years.
Results:
The CT revealed bronchial wall thickening (in 94% of the patients), atelectasis (in 73%), ground glass opacities (in 53%), focal hyperinflation (in 44%), fibrosis (in 29%) and bronchiectasis (in 26%). The extrapulmonary abnormalities were scoliosis (79%) and esophageal dilatation (35%). Silent fractures were noted in two vertebral bodies and one rib.
Conclusions:
Pulmonary changes were consistent with chronic inflammation in the bronchi and interstitial tissues. Ground glass opacities and fibrosis support the theory that these changes could be due to gastric aspiration. Bronchiectasis is less frequent. Esophageal dilatation with fluid overflow adds to aspiration. Fractures can be asymptomatic and are often missed.
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