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Updated: Jun 18, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Two new tropane alkaloids from the bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae)
Emerson F Queiroz1, Boris Zanolari, Andrew Marston
1Department of Research and Development, Aché Laboratórios Farmacêuticos S.A. Rodovia Presidente Dutra, km 222,2. Guarulhos-SP, cep 07034-904, Brazil. emerson.queiroz@ache.com.br
Abstract:
Two new tropane alkaloid N-oxides substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae), a Brazilian indigenous plant, locally known as catuaba and used in traditional medicine as an aphrodisiac. The alkaloid structures were determined by a combination of high resolution mass spectrometry and multi-dimensional NMR spectroscopy.
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