Related Experiment Video
Updated: Jun 18, 2026

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry
Published on: June 8, 2022
Eight-coordinate Zn(II), Cd(II), and Pb(II) complexes based on a 1,7-diaza-12-crown-4 platform endowed with a
Raquel Ferreirós-Martínez1, David Esteban-Gómez, Andrés de Blas
1Departamento de Química Fundamental, Universidade da Coruña, Campus da Zapateira, Alejandro de la Sota 1, Spain.
Abstract:
The thermodynamic stability of the Pb(II), Cd(II), Zn(II), and Ca(II) complexes with the dianionic macrocyclic ligand N,N'-bis[(6-carboxy-2-pyridyl)methyl]-1,7-diaza-12-crown-4 (H(2)bp12c4) has been investigated by pH-potentiometric titrations at 25 degrees C in 0.1 M KNO(3). The stability constants vary in the following order: Cd(II) > Zn(II) approximately Pb(II) > Ca(II). As a consequence, H(2)bp12c4 present an important Cd(II)/Ca(II) selectivity, as well as a certain selectivity for Cd(II) over Zn(II). To rationalize these results, a detailed investigation of the structure of these complexes has been carried out both in solid state and in aqueous solution. Furthermore, the [M(bp12c4)] complexes (M = Ca, Zn, Cd, or Pb) were characterized by means of density functional theory (DFT) calculations (B3LYP model) to obtain information on their solution structures and to investigate the possible stereochemical activity of the Pb(II) lone pair. Our results show that in all cases the metal ion is octacoordinated by the ligand, a situation that is particularly rare for Zn(II) complexes. The coordination polyhedra observed in the solid state for the [M(bp12c4)] complexes (M = Zn, Cd, or Ca) is closely related to the conformation adopted by the ligand in the corresponding complex: The Zn(II) complex adopts a Delta(lambdalambdalambdalambda) conformation in the solid state, which results in a square antiprismatic coordination, while the Delta(deltadeltadeltadelta) conformation observed for the Cd(II) and Ca(II) analogues yields inverted-square antiprismatic geometries. The X-ray crystal structure of the Pb(II) analogue shows that the metal ion is directly bound to the eight donor atoms of the ligand, but the bond distances of the metal coordination environment indicate an asymmetrical coordination of the cation by the ligand, which is attributed to the stereochemical activity of the Pb(II) lone pair. In aqueous solution the Ca(II), Zn(II), and Cd(II) complexes show rigid C(2) symmetries, while the Pb(II) analogue presents a more flexible structure.
More Related Videos
Related Concept Videos
Valence Bond Theory
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Coordination Compounds and Nomenclature
Coordination Number and Geometry
Complexometric Titration: Ligands

