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Updated: Jun 18, 2026

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
Published on: November 25, 2025
Hypomania with hypersexuality following bilateral anterior limb stimulation in obsessive-compulsive disorder
Chun-Hung Chang1, Shin-Yuan Chen, Yi-Ling Hsiao
1Department of Psychiatry, Buddhist Tzu-Chi General Hospital and University, Hualien City, Taiwan, Republic of China.
Abstract:
This 28-year-old Chinese man was referred for deep brain stimulation (DBS) evaluation for an 8-year history of refractory obsessive-compulsive disorder. After the patient had signed an informed consent, the authors implanted DBS leads. Hypomania with hypersexuality was noted on stimulation at Contact 2 and became aggravated with a higher voltage (> or = 3 V) during chronic bilateral DBS. After the voltage was decreased to 1 V, the patient's hypomanic symptoms subsided and his libido returned to baseline.
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