Related Experiment Video
Updated: Jun 18, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Polidocanol for endovenous microfoam sclerosant therapy
1University of Pennsylvania, 331 John Morgan Building/6112, 3620 Hamilton Walk, Philadelphia, PA 19104-4215, USA. eckmanndm@uphs.upenn.edu
Background:
Polidocanol is a liquid surfactant having endothelial cell lytic properties. In the form of a controlled, dispensed microfoam it is administered endovenously as a sclerosing agent in the treatment of varicose veins.
Objective:
This review summarizes efficacy of polidocanol endovenous microfoam sclerotherapy using a proprietary dispensing system to control foam characteristics and gas content for treating varicose veins.
Methods:
We reviewed in vitro, Phase I, Phase II and limited Phase III data for polidocanol microfoam with a focus on controlled foam formulation in therapy.
Results/Conclusions:
Clinical trials of controlled dispensing of polidocanol microfoam provide evidence of effective treatment of chronic venous insufficiency with low toxicity, minimal risk and few complications.
More Related Videos
Related Concept Videos
Ophthalmic Drug Delivery Systems
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Diabetic Foot Ulcer
Drugs for Treatment of Ulcerative Colitis in IBD
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis III: Interprofessional Care

