Unusual CNS infection from a subtorcular dermal sinus

P M Kanev1, J C Salazar

  • 1Department of Pediatric Neurosurgery, Connecticut Children's Medical Center, Hartford, CT, USA. pkanev@ccmckids.org

Abstract

Insights

A toddler

Area of Science:

  • Pediatric Neurosurgery
  • Infectious Diseases
  • Medical Imaging

Background:

  • Dermal sinus tracts are congenital anomalies that can lead to central nervous system (CNS) infections.
  • Hydrocephalus and increased intracranial pressure are serious complications of CNS infections.

Observation:

  • A 14-month-old toddler presented with symptoms of hydrocephalus and raised intracranial pressure.
  • Imaging revealed a posterior fossa dermoid mass associated with a previously unrecognized dermal sinus tract.
  • Cerebrospinal fluid (CSF) and subdural empyema cultures were positive for Staphylococcus aureus and Escherichia coli.

Findings:

  • This case represents the first reported instance of a dermoid mass and CNS infection with Staphylococcus aureus and Escherichia coli originating from a dermal sinus tract.
  • The unusual pathogens highlight the importance of considering underlying anatomical abnormalities in CNS infections.

Implications:

  • Children with CNS infections involving unusual pathogens require thorough evaluation for congenital anomalies like dermal sinus tracts.
  • Early identification of dermal sinus tracts can prevent severe neurological complications.
  • This case underscores the need for a multidisciplinary approach in diagnosing and managing complex pediatric neurosurgical cases.

Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...