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Updated: Jun 18, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Detection of pulmonary complications in common variable immunodeficiency
Catharina M L Touw1, Annick A van de Ven, Pim A de Jong
1Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht and Wilhelmina Children's Hospital, Utrecht, The Netherlands.
Summary
Pulmonary complications are common in common variable immunodeficiency (CVID). High-resolution computed tomography (HRCT) is the most sensitive imaging technique for detecting these lung issues in CVID patients.
Area of Science:
- Immunology
- Pulmonology
- Radiology
Background:
- Pulmonary complications are frequently observed in patients with common variable immunodeficiency (CVID).
- Early and accurate diagnosis of these complications is crucial for patient management.
- Existing diagnostic methods may not fully capture the extent of lung involvement.
Purpose of the Study:
- To review the literature on radiologic imaging techniques and pulmonary function tests (PFT) for diagnosing pulmonary complications in CVID.
- To assess the sensitivity and utility of different diagnostic modalities.
Main Methods:
- A literature review was conducted using PubMed and Embase databases.
- Searched for scientific publications on CVID, pulmonary complications, PFT, chest X-ray (CXR), and high-resolution computed tomography (HRCT).
- Included 26 articles encompassing 1047 patients, with 587 diagnosed with CVID.
Main Results:
- Up to 73% of CVID patients develop chronic structural pulmonary complications, primarily bronchiectasis and bronchial wall thickening.
- High-resolution computed tomography (HRCT) is the most sensitive method, identifying abnormalities missed by CXR and PFT in 2-59% of cases.
- Obstructive flow-volume curves on PFT were common, occurring in 50-94% of patients.
Conclusions:
- HRCT is a vital diagnostic tool for pulmonary complications in CVID at diagnosis and during follow-up.
- The optimal follow-up interval for HRCT in CVID patients requires further determination.
- Comprehensive evaluation using HRCT is recommended for accurate assessment of lung disease in CVID.
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