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Related Experiment Video

Updated: Jun 18, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

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Published on: July 13, 2019

Plasma cell infiltrates in polyomavirus nephropathy.

Eva Kemény¹, Hans H Hirsch, József Eller

¹Department of Pathology, University of Szeged, Szeged, Hungary.

Transplant International : Official Journal of the European Society for Organ Transplantation

|November 17, 2009

Summary

Polyomavirus-associated nephropathy (PVAN) involves specific plasma cells (PCs). IgM-producing PCs in kidney biopsies correlate with anti-BK virus IgM antibodies, suggesting PVAN infection.

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Merkel Cell Polyomavirus Infection and Detection

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Area of Science:

Nephrology
Immunology
Virology

Background:

Polyomavirus-associated nephropathy (PVAN) is a significant cause of kidney transplant dysfunction.
The role of plasma cells (PCs) in PVAN pathogenesis remains poorly characterized.

Purpose of the Study:

To characterize plasma cells in PVAN kidney biopsies.
To correlate plasma cell findings with clinical, morphological, and serological data.

Main Methods:

Immunohistochemistry and morphometry were used to analyze plasma cells in 20 PVAN cases.
Results were correlated with clinical, morphological, and anti-BK virus serological findings.

Main Results:

PC-rich infiltrates (>15% PCs) were found in 50% of cases.
IgM-producing PCs were common (70%), with predominance in 50% of cases.
IgM PC counts correlated significantly with serum IgM antibodies against BK virus (anti-BKV).

Conclusions:

IgM PC presence in biopsies indicates active PVAN infection.
PC-rich infiltrates with IgM PCs and negative C4d staining in peritubular capillaries suggest initiating PVAN infection investigation.