Related Experiment Video
Updated: Jun 18, 2026

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
Published on: June 6, 2025
[Evaluation and maintenance of heart donors]
R Hinojosa1, A Herruzo, A M Escoresca Ortega
1Servicio de Cuidados Críticos y Urgencias, Hospital Universitario Virgen del Rocío, Seville, Spain. rafahino3@yahoo.es
Insights
Donor scarcity limits heart transplantation for end-stage heart failure. Strategies like optimizing donor selection, expanding criteria, and improving organ maintenance are crucial to increase transplant rates.
Area of Science:
- Cardiology
- Transplantation Medicine
- Organ Donation
Context:
- Heart transplantation is the optimal treatment for end-stage heart failure refractory to conventional therapies.
- A significant disparity exists between the demand for and supply of donor hearts, limiting transplant numbers.
Purpose:
- To outline strategies for increasing heart transplantation rates.
- To address the critical issue of donor organ scarcity in heart transplantation.
Summary:
- Effective strategies are needed to bridge the gap between donor organ supply and patient demand.
- Key strategies include optimizing donor selection, expanding eligibility criteria for donors, and improving the physiological maintenance of procured organs.
- Future advancements like hormone replacement therapy and genomic evaluation may further enhance outcomes.
Impact:
- Increased heart transplant rates are anticipated through improved donor utilization and organ preservation.
- Enhanced donor management and recipient prognoses will be facilitated by these proposed strategies.
- These advancements aim to improve the quality of life and survival for patients with terminal heart failure.
Abstract:
Heart transplantation is currently the best treatment option to improve hope and quality of life in patients with terminal heart failure that is refractory to conventional treatment. The scarcity of donors remains a difficult problem and is the main factor limiting the number of transplants that can be performed. Given the current situation of stagnation and disparity between the number of potential organ donors, actual donors, and patients requiring transplants, we need effective strategies to reduce the differences between supply and demand and to ensure the best possible prognosis in organ recipients. These strategies should aim to ensure optimal donor selection. Likewise, it is essential to increase the number of potential donors by widening the criteria for donation and to improve our ability to take advantage of suboptimal donors. Moreover, we need to achieve acceptable physiological maintenance of donated organs. All these actions, together with the standardization of future treatments like hormone replacement therapy and genomic evaluation, will undoubtedly lead to an increase in the rate of transplants in the short and mid term, because the option of heart transplantation continues to have only slight repercussions in the high prevalence of terminal heart failure in our environment.
Related Concept Videos
Cardiomyopathy V: Interprofessional Care
Kidney Transplant I: Introduction
Cardiomyopathy II: Dilated Cardiomyopathy
Heart Failure VI: Adjunct Therapies
Cardiomyopathy VII: Pre and Post Operative Nursing Management

