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Differences in accessory pathway location by sex and race
Jonathan C Hsu1, Ronn E Tanel, Byron K Lee
1University of California, San Francisco, CA, USA.
Heart Rhythm
|November 17, 2009
Summary
Accessory pathway (AP) formation may have a genetic basis, as location differs significantly by sex and race. Females showed more right annular APs, while Asians had more right anterior APs.
Area of Science:
- Cardiology
- Genetics
- Electrophysiology
Background:
- The origins of accessory pathway (AP) formation remain largely unknown.
- Investigating potential genetic links is crucial for understanding AP development.
Purpose of the Study:
- To test the hypothesis that AP formation is genetically influenced.
- To examine if AP location varies by sex and race, using these as proxies for genetic differences.
Main Methods:
- A retrospective cohort study of 282 patients undergoing their first electrophysiology study for APs.
- Comparison of patient sex and race with AP location determined via invasive electrophysiology.
Main Results:
- Females had a higher prevalence of right annular APs (57%) compared to males (32%), with 2.8-fold increased odds after adjustment.
- Asians showed a significantly higher incidence of right anterior APs (26%) compared to other races (12%), with 3.8-fold increased odds after adjustment.
Conclusions:
- Significant sex and race-based variations in AP location suggest a potential genetic component in AP formation.
- These findings highlight the need for further research into the genetic underpinnings of accessory pathway development.
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