Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Breathing I: Inspiration01:30

Mechanism of Breathing I: Inspiration

Introduction to Inspiration: The Respiratory System in Action
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
Application of Integration: Problem Solving01:30

Application of Integration: Problem Solving

The process of breathing involves the periodic intake and expulsion of air, known as the respiratory cycle, which typically lasts about five seconds. Modeling the volume of air inhaled into the lungs as a function of time provides insight into both the dynamics and efficiency of pulmonary ventilation. This volume is determined by integrating the airflow rate over time, which captures the cumulative effect of air entering the lungs.Sinusoidal Model of AirflowAirflow during respiration is not...
Pulmonary Ventilation: Inhalation01:24

Pulmonary Ventilation: Inhalation

Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
Mechanism of Breathing II: Expiration01:23

Mechanism of Breathing II: Expiration

The Physiology of Expiration: A Seamless Respiratory Process
Expiration, or exhaling, is a complex physiological process that begins as the inspiratory muscles begin to relax. This relaxation triggers a series of events that epitomize the efficiency of the respiratory system.
Mechanism of Expiration:
Mechanism of Breathing III: The Accessory Muscles01:21

Mechanism of Breathing III: The Accessory Muscles

The Role of Accessory Muscles in the Respiratory System
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive function depends upon <i>Satb2</i> gene dosage in cortical projection neurons.

bioRxiv : the preprint server for biology·2026
Same author

Feature-specific threat coding in lateral septum guides defensive action.

Nature·2026
Same author

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Nature·2026
Same author

Non-reciprocal callosal projections and input gradients underlie interhemispheric communication in binocular visual cortex.

Cell reports·2026
Same author

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

Research square·2025
Same author

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

bioRxiv : the preprint server for biology·2025
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
09:08

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Published on: November 21, 2023

Math1: waiting to inhale.

Robert P Machold1, Gord Fishell

  • 1Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, NY 10016, USA. robert.machold@med.nyu.edu

Neuron
|November 17, 2009
PubMed
Summary
This summary is machine-generated.

The proneural gene Math1 is crucial for developing brainstem regions. This gene impacts conscious proprioception, interoception, and respiration, expanding its known nervous system functions.

More Related Videos

Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy
08:23

Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy

Published on: November 10, 2023

Breath Collection from Children for Disease Biomarker Discovery
06:09

Breath Collection from Children for Disease Biomarker Discovery

Published on: February 14, 2019

Related Experiment Videos

Last Updated: Jun 18, 2026

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
09:08

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Published on: November 21, 2023

Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy
08:23

Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy

Published on: November 10, 2023

Breath Collection from Children for Disease Biomarker Discovery
06:09

Breath Collection from Children for Disease Biomarker Discovery

Published on: February 14, 2019

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • The proneural gene Math1 (also known as ATmathbb{RDL1}) has established roles in the nervous system, including unconscious proprioception, audition, and arousal.
  • Previous research indicated Math1's involvement in various neural functions.

Discussion:

  • Recent studies highlight Math1's critical role in the development of specific brainstem regions.
  • These brainstem areas are essential for vital functions such as conscious proprioception, interoception, and respiration.

Key Insights:

  • Math1 is indispensable for the proper development of neural circuits controlling conscious sensory processing and autonomic functions.
  • The findings reveal a previously unrecognized function of Math1 in the development of brainstem nuclei.

Outlook:

  • Further investigation into Math1's regulatory mechanisms could offer insights into neurological disorders affecting sensory and respiratory control.
  • Understanding Math1's developmental role may pave the way for therapeutic strategies targeting brainstem development and function.