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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Related Experiment Video

Updated: Jun 18, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

MicroRNAs potentiate neural development.

Sarah K Fineberg¹, Kenneth S Kosik, Beverly L Davidson

¹Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242 USA.

|November 17, 2009

Summary

This summary is machine-generated.

MicroRNAs (miRNAs) are crucial noncoding RNAs regulating gene expression. These molecules play a vital role in vertebrate neural development, influencing cell-fate decisions and nervous system formation.

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Last Updated: Jun 18, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

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Published on: April 12, 2015

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

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Published on: October 9, 2020

Murine Neural Plate Targeting by In Utero Nano-Injection (NEPTUNE) at Embryonic Day 7.5

Murine Neural Plate Targeting by In Utero Nano-Injection (NEPTUNE) at Embryonic Day 7.5

Published on: February 14, 2022

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression post-transcriptionally.
Vertebrate brains exhibit a higher diversity of miRNA expression compared to other tissues.
miRNAs are implicated in various biological processes, including development and cell differentiation.

Purpose of the Study:

To investigate the role of microRNAs in neural development.
To understand how miRNAs influence cell-fate decisions during embryogenesis.
To elucidate the broader functions of miRNAs in nervous system development.

Main Methods:

Review of recent literature on miRNA function in development.
Analysis of studies involving miRNA depletion during neural commitment.
Comparative analysis of miRNA expression patterns in different tissues.

Main Results:

Specific miRNAs have demonstrated significant effects during developmental processes.
miRNA depletion studies indicate their essential role in neural commitment.
Evidence supports a requisite function for miRNAs in cell-fate decisions.

Conclusions:

MicroRNAs are essential regulators of neural development in vertebrates.
miRNAs are critical for making cell-fate decisions during nervous system formation.
Further research into miRNA function can provide insights into nervous system development.