Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

65.7K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
65.7K
Cell Migration01:09

Cell Migration

18.5K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.5K
Cell Migration01:19

Cell Migration

6.3K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.3K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.4K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.4K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

3.1K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.1K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

4.3K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

isl1a coordinates onset and termination of regeneration of the zebrafish lateral line.

NPJ Regenerative medicine·2026
Same author

Cell death modalities modulate inflammatory and regenerative programs in zebrafish sensory organs.

Nature communications·2026
Same author

prdm1a drives a fate switch between hair cells of different mechanosensory organs.

Nature communications·2025
Same author

Paired and solitary ionocytes in the zebrafish olfactory epithelium.

Chemical senses·2025
Same author

Stem and progenitor cell proliferation are independently regulated by cell type-specific cyclinD genes.

Nature communications·2025
Same author

<i>prdm1a</i> drives a fate switch between hair cells of different mechanosensory organs.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 9, 2026

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy
05:50

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy

Published on: November 1, 2021

2.8K

Cell migration during morphogenesis.

Andy Aman1, Tatjana Piotrowski

  • 1University of Utah, Department Neurobiology and Anatomy, 20N Medical Drive, MREB 401, Salt Lake City, UT 84132, USA.

Developmental Biology
|November 17, 2009
PubMed
Summary

Cell migration is vital for development and disease. This review integrates insights from diverse in vivo models to illuminate the regulation of morphogenic cell movements, crucial for both normal development and pathological conditions like cancer metastasis.

More Related Videos

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

24.2K
In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

140.8K

Related Experiment Videos

Last Updated: Jan 9, 2026

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy
05:50

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy

Published on: November 1, 2021

2.8K
Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

24.2K
In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

140.8K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Cancer Biology

Background:

  • Cellular migration is essential for forming correct three-dimensional structures during development.
  • Aberrant cell migration contributes to pathological conditions, including cancer invasion and metastasis.
  • Cells migrate individually, in sheets, or as clusters, necessitating diverse regulatory mechanisms.

Purpose of the Study:

  • To summarize and compare knowledge from various in vivo model systems studying morphogenic cell migration.
  • To integrate recent advances in understanding the regulation of cell migration across different contexts.
  • To highlight insights into both individual and collective cell movement regulation.

Main Methods:

  • Review and synthesis of data from multiple established in vivo model systems.
  • Comparative analysis of cell migration regulation across diverse biological contexts.
  • Phenotypic description of model systems used for in vivo cell migration studies.

Main Results:

  • Diverse model systems, including zebrafish, Drosophila, and mouse models, offer insights into cell migration.
  • Understanding cell migration in vivo is critical for both embryonic development and postembryonic events.
  • Key regulatory mechanisms governing individual and collective cell movements are being elucidated.

Conclusions:

  • Studying cell migration in vivo across multiple model systems provides broad insights into fundamental biological processes.
  • Insights gained are applicable to understanding both normal morphogenesis and diseases like cancer.
  • Further integration of knowledge from varied systems will advance our understanding of cell migration regulation.