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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Progress towards personalized medicine.

Stewart Bates¹

¹Director Biomarker Discovery, Biopharm R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. stewart.a.bates@gsk.com

Drug Discovery Today

|November 17, 2009

Summary

This summary is machine-generated.

Personalized medicine tailors treatments to patient subgroups using genomic insights for better outcomes. While molecularly targeted therapies advance drug development, realizing personalized medicine's full promise requires further progress.

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Area of Science:

Genomics
Pharmacology
Molecular Pathology

Background:

Personalized medicine aims to tailor therapies based on individual patient response or adverse event risk.
Advancements in genomic technologies have significantly improved understanding of molecular disease pathology.
This allows for disease redefinition at a molecular level, paving the way for targeted treatments.

Purpose of the Study:

To assess the current progress of personalized medicine.
To evaluate the proximity of personalized medicine to fulfilling its potential in healthcare.
To examine the impact of molecularly targeted therapies and diagnostic criteria on drug development.

Main Methods:

Review of advancements in genomic tools and molecular pathology.
Analysis of the development and application of molecularly targeted therapies.
Evaluation of diagnostic criteria evolution in the context of personalized medicine.

Main Results:

Genomic tools have enhanced the understanding of molecular disease mechanisms.
Molecularly targeted therapies are increasingly being developed.
Improved diagnostic criteria are emerging to support personalized approaches.

Conclusions:

Personalized medicine has made significant strides, driven by genomic insights and targeted therapies.
The integration of molecular diagnostics is redefining disease classification and treatment strategies.
While promising, the full realization of personalized medicine's potential is an ongoing process requiring continued research and development.