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Related Concept Videos

Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
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Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Hemoglobin01:24

Hemoglobin

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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Carbon Dioxide Transport in the Blood01:19

Carbon Dioxide Transport in the Blood

Carbon dioxide (CO2) transport in the blood is critical to human physiology. On average, our body cells produce around 200 mL of CO2 per minute, precisely the quantity expelled by the lungs. This process involves the transportation of CO2 from the tissue cells to the lungs in three primary forms.
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Red cell storage.

John R Hess1

  • 1University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. jhess@umm.edu

Journal of Proteomics
|November 17, 2009
PubMed
Summary
This summary is machine-generated.

Blood component storage improves safety and availability but can decrease efficacy. Research is exploring the "storage lesion" to enhance future blood products.

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11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

Area of Science:

  • Transfusion Medicine
  • Biotechnology
  • Biochemistry

Background:

  • Blood component storage enables temporal and spatial separation of donors and recipients, transforming transfusions into a planned medical logistic activity.
  • This process enhances blood product availability and safety but may compromise the efficacy of transfused components due to storage-induced changes.

Purpose of the Study:

  • To review the multifaceted changes in red blood cells during storage, known as the "red cell storage lesion."
  • To discuss the challenges in demonstrating the clinical significance of these storage-induced alterations.
  • To highlight the potential of advanced techniques like proteomics and metabolomics in understanding blood storage and improving future products.

Main Methods:

  • Literature review of studies on red blood cell storage.
  • Analysis of described changes in red cell metabolism, shape, rheology, membrane composition, and function.
  • Discussion of the clinical impact of the "storage lesion" and future research directions.

Main Results:

  • Storage leads to a "storage lesion" characterized by metabolic alterations, shape changes, reduced flow properties, membrane damage, and impaired oxygen delivery.
  • Accumulation of leaked potassium and potential bacterial contamination are also noted storage-related issues.
  • Despite documented changes, direct clinical effects of the storage lesion remain difficult to definitively prove, leading to conservative regulatory decisions.

Conclusions:

  • The "red cell storage lesion" encompasses a wide range of detrimental changes to stored blood components.
  • Demonstrating the clinical relevance of these changes is crucial for optimizing storage protocols and regulatory guidelines.
  • Proteomics and metabolomics offer promising avenues for a deeper understanding of blood storage and the development of improved clinical products.