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Randomized clinical trials in gastrointestinal stromal tumors

Peter A Learn1, Jason K Sicklick, Ronald P DeMatteo

  • 1Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 203, New York, NY 10065, USA.

Surgical Oncology Clinics of North America
|November 17, 2009
PubMed

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...