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Updated: Jun 18, 2026
06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Effect of cushing response on systemic arterial pressure
Mauro Ursino1, Massimo Giannessi, Marta Frapparelli
1Dipartimento di Elettronica, Informatica e Sistemistica, Via Venezia 52, I- 47023 Cesena, Italy. mauro.ursino@unibo.it
Summary
This study models cerebrovascular dynamics, intracranial pressure (ICP), and the Cushing response. It reveals conditions for arterial pressure waves and aids clinicians in balancing the Cushing response
Area of Science:
- Physiology
- Biomedical Engineering
- Mathematical Modeling
Background:
- Cerebrovascular dynamics are crucial for brain health.
- Intracranial pressure (ICP) regulation is complex.
- The Cushing response is a critical but poorly understood physiological mechanism.
Purpose of the Study:
- To investigate the interplay between cerebrovascular dynamics, ICP, and the Cushing response.
- To analyze the effects of the Cushing response on cardiovascular and cerebrovascular parameters.
- To identify conditions leading to systemic instability and arterial pressure waves.
Main Methods:
- Development of an original mathematical model.
- Simulation of constant ICP elevation.
- Analysis of ICP plateau waves.
- Investigation of system instability and wave formation.
Main Results:
- The model elucidates the Cushing response's impact on cardiovascular and cerebrovascular metrics.
- Identified conditions for slow arterial pressure wave generation (0.05-0.1 Hz).
- Demonstrated the model's utility in analyzing ICP dynamics.
Conclusions:
- The mathematical model provides insights into cerebrovascular regulation.
- Understanding these dynamics can help manage conditions involving elevated ICP.
- The model may assist clinicians in balancing the benefits and risks of the Cushing response.
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