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Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations
K H Ott1, S Becker, R D Gordon
1Institut für Biophysikalische Chemie, J.W. Goethe Universität, Frankfurt am Main, Germany.
FEBS Letters
|January 28, 1991
Abstract:
We have investigated the structure of mu-conotoxin GIIIA by 2D-NMR methods. The assignment of 1H NMR spectra and a quantitative analysis of NOE and J-coupling data are presented. These results were used for the calculation of secondary structure elements of mu-conotoxin GIIIA. Distance geometry calculations were carried out to define the global folding of the peptide.