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Related Experiment Video

Updated: Jun 18, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria

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Published on: October 25, 2024

Fosfomycin: an old, new friend?

M Popovic¹, D Steinort, S Pillai

¹Department of Cardiovascular and Interventional Radiology, Medical University of Vienna, Vienna, Austria.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology

|November 17, 2009

Summary

Fosfomycin (FOM) is a versatile antibiotic with a broad global usage history. Its efficacy against resistant bacteria like MRSA and ESBL is being re-evaluated for modern therapeutic applications.

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Area of Science:

Pharmacology and Microbiology
Antimicrobial resistance
Infectious diseases

Background:

Fosfomycin (FOM) usage varies globally, with broader applications in Europe, Japan, South Africa, and Brazil compared to the US.
Initial skepticism regarding FOM's in vitro activity has been overcome by extensive research and improved microbiological understanding since the 1970s.
FOM has undergone 40 years of pre-clinical and clinical evaluation across diverse settings and applications.

Observation:

Intravenous FOM-disodium is widely accepted in Europe for treating soft tissue infections, sepsis, and deep-seated infections.
Emerging antibiotic-resistant bacteria, including MRSA, ESBL, and MSSA, necessitate the revival of established antimicrobial agents like FOM.
Comprehensive pharmacokinetic and pharmacodynamic data support FOM's efficacy in large-scale studies.

Findings:

FOM demonstrates proven efficacy in a wide range of clinical applications.
Intravenous FOM-disodium is a well-established treatment option in many European countries.
FOM's characteristics make it a candidate for combating modern resistant bacterial strains.

Implications:

Revisiting and expanding the use of Fosfomycin is crucial for addressing current challenges in antimicrobial resistance.
Further research into FOM's mode of action, resistance, and combination therapies can optimize its clinical utility.
FOM's established safety and efficacy profile supports its consideration for broader indications, including against resistant pathogens.