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Related Concept Videos

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

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Establishment of a Minimally Invasive Rat Model of Pulmonary Embolism Using Autologous Blood Clots
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Looking for the ideal particle: an experimental embolization study.

Cagin Senturk1, Volkan Cakir, Kutsal Yorukoglu

  • 1Endovascular and Percutaneous Therapy Service, Hospital Ntra. Señora del Rosario, Madrid, Spain. caginsenturk@yahoo.com

Cardiovascular and Interventional Radiology
|November 17, 2009
PubMed
Summary
This summary is machine-generated.

Expanding microspheres (EXMs) showed a high recanalization rate and less infarction, indicating lower efficiency in rabbit kidney embolization. Tris-acryl gelatin microspheres (TGMs) demonstrated the most effective embolization in this study.

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Area of Science:

  • Interventional Radiology
  • Vascular Embolization
  • Biomaterials Science

Background:

  • Embolization is a key interventional radiology technique.
  • Selection of embolic material impacts procedure outcomes.
  • Comparative studies are needed to guide clinical choices.

Purpose of the Study:

  • To compare the efficacy of four commonly used embolic particles in a rabbit renal artery embolization model.
  • To evaluate particle characteristics, including recanalization, inflammation, and infarct volume.

Main Methods:

  • Right renal arteries of 16 rabbits were embolized with Polyvinyl Alcohol (PVA) particles, PVA microspheres (PVAMs), Tris-acryl gelatin microspheres (TGMs), or Expanding Microspheres (EXMs).
  • Quantities used, embolization time, and angiographic patterns were recorded.
  • Histopathology and infarct volume analysis were performed 14 days post-embolization.

Main Results:

  • Expanding microspheres (EXMs) required significantly less material but exhibited 100% recanalization, unlike PVA and TGM groups (0%).
  • Tris-acryl gelatin microspheres (TGMs) showed no extravasation and no neocapillarization, with the most efficient embolization.
  • EXMs and PVA groups had higher extravasation rates and inflammation compared to TGMs. PVA and PVAMs showed neocapillarization, absent in TGM and EXM groups.

Conclusions:

  • Expanding microspheres (EXMs) are less efficient due to high recanalization and minimal infarction in rabbit kidneys.
  • Tris-acryl gelatin microspheres (TGMs) provide the most efficient embolization among the tested agents in this model.
  • Findings suggest TGM is a superior embolic agent for renal artery embolization compared to PVA, PVAMs, and EXMs in rabbits.