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Updated: Jun 18, 2026
Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
Published on: February 11, 2014
Establishment and characterization of human bladder cancer cell lines BexBra1, BexBra2, and BexBra4
Camila B Piantino1, Juliana M Sousa-Canavez, Victor Srougi
1Laboratory of Medical Investigation, Urology Department–LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil.
Abstract:
Bladder cancer (BC) is the fourth most common cancer in the USA. In Brazil, BC represents 3% of the total existing carcinomas in the population and represents the second highest incidence among urological tumors. The majority of bladder cancer cell lines available were derived from Caucasians and established in the seventies or eighties. Thus, neoplasia development in these cells likely occurred in environment conditions vastly different than today. In the present study, we report the establishment and characterization of three Brazilian bladder cancer cell lines (BexBra1, BexBra2, and BexBra4). These cell lines may be helpful for dissecting the genetic and epigenetic aspects that trigger the progression of BC. Moreover, the development of a Brazilian representative of the disease will allow us to investigate the potential inter-racial differences of malignancy-associated phenotypes in bladder cancer.
