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Updated: Jun 18, 2026
06:47
A Murine Model of Vertical Sleeve Gastrectomy
Published on: December 18, 2017
Early postoperative insulin-resistance changes after sleeve gastrectomy
Mario Rizzello1, Francesca Abbatini, Giovanni Casella
1Surgical-Medical Department for Digestive Diseases, Policlinico Umberto I, University Sapienza, Viale del Policlinico, 00161 Rome, Italy.
Obesity Surgery
|November 17, 2009
Summary
Sleeve gastrectomy rapidly improves insulin resistance in obese patients with type 2 diabetes within days of surgery, independent of weight loss. This suggests hormonal factors play a key role in enhancing insulin action post-procedure.
Area of Science:
- Bariatric surgery
- Metabolic disorders
- Endocrinology
Background:
- Bariatric surgeries like biliopancreatic diversion and gastric bypass rapidly improve insulin resistance.
- Sleeve gastrectomy (SG) is a bariatric procedure for which short-term effects on insulin resistance require evaluation.
Purpose of the Study:
- To assess the short-term impact of laparoscopic sleeve gastrectomy (SG) on insulin resistance in obese patients with type 2 diabetes.
Main Methods:
- Seventeen obese patients with type 2 diabetes underwent laparoscopic SG.
- Fasting glucose, insulin, and HOMA IR were measured preoperatively and up to 60 days post-SG.
- Insulin sensitivity was assessed in seven patients on postoperative days 1-4.
- A control group of three overweight diabetic patients underwent laparoscopic cholecystectomy.
Main Results:
- Laparoscopic SG led to a significant reduction in glucose, insulin, and HOMA IR within 5 days, persisting at 15 days.
- These improvements were observed before significant weight loss occurred.
- In the control group, only glucose levels decreased by postoperative day 5.
Conclusions:
- Sleeve gastrectomy rapidly enhances insulin action, independent of excess weight loss (EWL).
- Hormonal mechanisms are likely contributors to the observed changes in insulin resistance post-SG.
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