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A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

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Altered callosal function in cerebral microangiopathy.

Matthias Wittstock¹, Annette Grossmann, Erwin Kunesch

¹Human Cortical Physiology Laboratory, Department of Neurology, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany. matthias.wittstock@med.uni-rostock.de

Journal of Neurology

|November 17, 2009

Summary

This summary is machine-generated.

Cerebral microangiopathy (CMA) significantly impacts corpus callosum function, leading to callosal dysfunction and atrophy. This study shows CMA extent correlates with impaired bimanual tapping and ipsilateral silent period, suggesting CMA

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Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

Area of Science:

Neuroscience
Neurology
Neuroimaging

Background:

Callosal dysfunction is a hallmark of central nervous system diseases.
Cerebral microangiopathy (CMA) may cause callosal pathway demyelination.
Understanding CMA's impact on the corpus callosum is crucial.

Purpose of the Study:

To investigate callosal function in relation to the extent of cerebral microangiopathy (CMA).
To correlate neurophysiological measures of callosal function with CMA severity and callosal atrophy.

Main Methods:

Bimanual tapping task and transcranial magnetic stimulation (TMS) to assess callosal function.
Analysis of ipsilateral silent period (iSP) and transcallosal conduction time (TCT).
Correlation of functional data with cerebral magnetic resonance imaging (cMRI) scores for CMA extent and callosal atrophy in 44 CMA patients and 10 controls.

Main Results:

Pathological iSP findings and disturbed bimanual tapping correlated significantly with higher CMA scores.
The extent of CMA was significantly correlated with the degree of callosal atrophy.
CMA significantly affects callosal pathways, likely through chronic demyelination.

Conclusions:

Cerebral microangiopathy considerably impacts corpus callosum pathways.
Callosal atrophy and dysfunction are linked to the extent of CMA.
Ipsilateral silent period (iSP) analysis can assess the clinical impact of CMA detected by cMRI.