[Local and systemic immunological disorders in patients with subretinal proliferation]

IgM, IgG, IgA, and IgE in the subretinal fluid (SRF) of the subpopulational composition of peripheral blood T lymphocytes and the parameters of a leukocyte migration inhibition test (LMIT) were comparatively studied in patients with posttraumatic and regmatogenic retinal detachments (RD) complicated by subretinal proliferation (SP). SRF and blood samples taken from 20 patients with SP of various etiologies were studied. SRF immunoglobulins of classes M, G, A, and E were revealed in all the examinees, their higher levels being noted in patients with long-standing (more than 4 months) and severe recurrent RD. Comparative examinations of patients with regmatogenic and posttraumatic RDs revealed a significantly higher content of T lymphocytes (CD3+), T killers (CD8+), and T helpers (CD4+) in the peripheral blood of patients with regmatogenic RD. The patients of both groups were found to have increased LMIT values with phytohemagglutinin, Con-A and retinal antigen, in Group 2, leukocyte migration inhibition with retinal antigens being much more pronounced than that in Group 1.