Related Experiment Video

Updated: Feb 1, 2026

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins
11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

9.4K

Age distribution of paediatric rotavirus gastroenteritis cases in Europe: the REVEAL study

Carlo Giaquinto1, Pierre van Damme,

  • 1Department of Paediatrics, University of Padua, Via Giustiniani 3, Padua, Italy. carlog@child.pedi.unipad.it

Scandinavian Journal of Infectious Diseases
|November 18, 2009
PubMed

Insights

Rotavirus gastroenteritis (RVGE) is a common cause of severe diarrhea in young children. This study found that most cases occur in children aged 3 months to 3 years, supporting early childhood vaccination.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Rotavirus is a leading cause of severe diarrhea in children under five years old.
  • Acute gastroenteritis (AGE) and rotavirus gastroenteritis (RVGE) represent a significant public health concern in young children.

Purpose of the Study:

  • To estimate the incidence of community-acquired AGE and RVGE in children under five.
  • To describe the age distribution of children with RVGE in Europe.

Main Methods:

  • A prospective, multicentre, observational study conducted across seven European countries during the 2004-2005 rotavirus season.
  • Inclusion of 2846 children with AGE seeking medical care in primary care, emergency departments, and hospitals.
  • ELISA testing used to confirm rotavirus positivity in 2712 children.

Main Results:

  • Rotavirus positivity was confirmed in 40.6% (1102/2712) of children with AGE.
  • The majority of rotavirus gastroenteritis (RVGE) cases, 86.1%, occurred in children aged 3 months to 3 years.
  • Infants under 3 months accounted for 1.8% of cases, and children over 4 years accounted for 3.6%.

Conclusions:

  • The findings highlight that the primary at-risk period for rotavirus gastroenteritis in Europe is early childhood.
  • Routine rotavirus vaccination for all infants in early childhood is recommended to mitigate the burden of this disease.
  • Vaccination during the peak incidence period could significantly reduce the impact of rotavirus gastroenteritis in children.

More Related Videos

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

9.4K
Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.2K

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
261
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
701
Drug Distribution: Volume of Distribution01:25

Drug Distribution: Volume of Distribution

The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.
7.4K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
F Distribution01:19

F Distribution

The F distribution was named after Sir Ronald Fisher, an English statistician. The F statistic is a ratio (a fraction) with two sets of degrees of freedom; one for the numerator and one for the denominator. The F distribution is derived from the Student's t distribution. The values of the F distribution are squares of the corresponding values of the t distribution. One-Way ANOVA expands the t test for comparing more than two groups. The scope of that derivation is beyond the level of this...
10.7K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.5K