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Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...

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Related Experiment Video

Updated: Jun 18, 2026

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Chronic localized intravascular coagulation complicating multifocal venous malformations.

Linda K Martin1, Susan Russell, Orli Wargon

  • 1Department of Paediatric Dermatology, Sydney Children's Hospital, Sydney, New South Wales, Australia.

The Australasian Journal of Dermatology
|November 18, 2009
PubMed
Summary

Two young girls with widespread venous malformations developed chronic localized intravascular coagulation. This condition, marked by elevated D-dimer, poses risks for serious bleeding and clotting disorders.

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Last Updated: Jun 18, 2026

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Area of Science:

  • Vascular Malformations
  • Hematology
  • Pediatric Medicine

Background:

  • Venous malformations (VMs) are common congenital vascular anomalies.
  • Chronic localized intravascular coagulation (CLIC) is a rare complication associated with large VMs.
  • Understanding CLIC in multifocal VMs is crucial for patient management.

Observation:

  • Two pediatric patients presented with extensive, multifocal VMs affecting skin, mucous membranes, and pharynx.
  • Advanced imaging (ultrasound, MRI) revealed the extent of VMs not evident clinically.
  • Both patients exhibited persistently elevated D-dimer levels, indicating CLIC.

Findings:

  • CLIC in these cases was associated with disseminated, multifocal VMs, not just large segmental ones.
  • One patient experienced thromboses after sclerotherapy, highlighting treatment risks.
  • Elevated D-dimer confirms ongoing coagulation activation within the malformations.

Implications:

  • CLIC in multifocal VMs necessitates careful monitoring for thrombohemorrhagic complications.
  • Early recognition and management of CLIC can prevent progression to disseminated intravascular coagulation.
  • These cases expand the understanding of CLIC occurrence in diverse venous malformation presentations.