Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age- and tissue-specific induction of NHE3 by glucocorticoids in the rat small intestine.

American journal of physiology. Cell physiology·2001
Same author

A single residue contributes to the difference between Kir4.1 and Kir1.1 channels in pH sensitivity, rectification and single channel conductance.

The Journal of physiology·2000
Same author

Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1 channels.

American journal of physiology. Cell physiology·2000
Same author

Interaction of different oligomeric states of hexameric DNA-helicase RepA with single-stranded DNA studied by analytical ultracentrifugation.

FEBS letters·2000
Same author

Function of GATA transcription factors in preadipocyte-adipocyte transition.

Science (New York, N.Y.)·2000
Same author

DNA helicase RepA: cooperative ATPase activity and binding of nucleotides.

Biochemistry·2000
Same journal

Acute Rejection Mediated by Preformed Anti-HLA-C Antibody in a Kidney Transplant Patient: A Case Report.

Transplantation proceedings·2026
Same journal

Liver Transplantation for Metastatic Neuroendocrine Tumors: A Single-Center Experience in a Brazilian Referral Center.

Transplantation proceedings·2026
Same journal

Analysis of the Cost of Maintaining Effective Donors and Nondonors of Organs and Tissues in Intensive Care Units.

Transplantation proceedings·2026
Same journal

Adolescence and Pediatric Heart Transplantation: Impact of Non-Adherence on Mortality: A Single-Center Experience.

Transplantation proceedings·2026
Same journal

Impact of Family-Based Care on the Outcome of Brain Death and Humanization in the Process of Multiple Organ Donation: Case Report.

Transplantation proceedings·2026
Same journal

Karnofsky Performance Status Is Associated with Patient and Graft Survival After Liver Retransplantation.

Transplantation proceedings·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Composite tissue allotransplantation: current challenges.

K V Ravindra1, S Wu, M McKinney

  • 1Department of Surgery, University of Louisville, Louisville, Kentucky, USA.

Transplantation Proceedings
|November 18, 2009
PubMed
Summary
This summary is machine-generated.

Composite tissue allotransplantation (CTA) shows promise in clinical applications like face and limb transplants. Overcoming immunosuppression challenges is key to advancing this field.

More Related Videos

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
09:30

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation

Published on: July 18, 2025

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
08:11

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jun 18, 2026

Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
09:30

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation

Published on: July 18, 2025

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
08:11

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

Area of Science:

  • Immunology
  • Transplantation Surgery
  • Regenerative Medicine

Background:

  • Composite tissue allotransplantation (CTA) is increasingly applied clinically, with successes in hand, face, knee, trachea, and laryngeal transplants.
  • Despite growing interest, reconstructive surgeons express skepticism due to concerns about immunosuppression risks.
  • Advancement in CTA is hindered by the toxicity of current immunosuppressive agents.

Purpose of the Study:

  • To review the current clinical and laboratory status of composite tissue allotransplantation.
  • To highlight the immunological challenges and potential solutions in CTA.
  • To emphasize the need for improved immunosuppressive strategies and tolerance induction.

Main Methods:

  • Review of current literature on clinical and laboratory-based composite tissue allotransplantation.
  • Analysis of the immunological principles underlying CTA success and failure.
  • Examination of existing and emerging immunosuppressive agents and tolerance induction methods.

Main Results:

  • CTA has demonstrated success in various clinical settings, including face and limb transplantation.
  • Immunosuppression remains a significant barrier, with current agents posing considerable risks.
  • Development of less toxic immunosuppressants and methods for donor-specific tolerance are crucial for progress.

Conclusions:

  • Composite tissue allotransplantation is a rapidly advancing field with significant clinical potential.
  • Addressing the risks associated with immunosuppression is paramount for wider adoption.
  • A deeper understanding of CTA immunology is essential for future breakthroughs and widespread application.