Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers, unexplained...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing realism of artificial intelligence-generated colorectal polyp images: International multicenter blinded reader study.

Endoscopy international open·2026
Same author

Impact of Neuroendocrine Neoplasm-Specific Systemic Treatments on Somatostatin Receptors Expression and Function in Neuroendocrine Tumor Cells.

Cancers·2026
Same author

Sustainability in endoscopic medical congresses and courses: Position Statement from the European Society of Gastrointestinal Endoscopy and the European Society of Gastroenterology and Endoscopy Nurses and Associates.

Endoscopy·2026
Same author

Gastrointestinal endoscopic image style transfer using EndoStyle to improve artificial intelligence prediction models.

NPJ digital medicine·2026
Same author

Prognostic impact of discordant lesions on [<sup>18</sup>F]FDG and [<sup>68</sup>Ga]Ga-FAPI-04 PET/CT compared to histological FAP expression in neuroendocrine neoplasms.

Frontiers in nuclear medicine·2026
Same author

Artificial intelligence assisted colorectal lesion detection in private practices a randomized controlled study.

NPJ digital medicine·2026
Same journal

Transform-The Path Forward: Endoscopy and the Science of Expertise.

Gastrointestinal endoscopy clinics of North America·2026
Same journal

Ushering in a New Era of Training in Endoscopy.

Gastrointestinal endoscopy clinics of North America·2026
Same journal

Where Do We Go from Here: Transforming Teaching Endoscopy Knowledge Using the Expert Performance Approach.

Gastrointestinal endoscopy clinics of North America·2026
Same journal

Integrating Artificial Intelligence into Endoscopy Training.

Gastrointestinal endoscopy clinics of North America·2026
Same journal

From Expert to Educator: Translating Expert Performance into Teachable Competencies Through Trainer Development in Endoscopic Simulation.

Gastrointestinal endoscopy clinics of North America·2026
Same journal

Implementing Endoscopy Simulation Nationally.

Gastrointestinal endoscopy clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique
06:31

Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique

Published on: January 10, 2013

Confocal endomicroscopy.

Alexander Meining1

  • 1Department of Medicine II, Klinikum rechts der Isar, Technical University of Munich, Ismaningerstr. 22, 81675 Munich, Germany. alexander.meining@lrz.tum.de

Gastrointestinal Endoscopy Clinics of North America
|November 18, 2009
PubMed
Summary
This summary is machine-generated.

Probe-based confocal laser endomicroscopy offers improved in vivo microscopic imaging for biliary neoplasms. This advanced technology shows promise in differentiating biliary and pancreatic strictures, though further patient studies are needed.

More Related Videos

Video-rate Scanning Confocal Microscopy and Microendoscopy
14:10

Video-rate Scanning Confocal Microscopy and Microendoscopy

Published on: October 20, 2011

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
13:49

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Related Experiment Videos

Last Updated: Jun 18, 2026

Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique
06:31

Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique

Published on: January 10, 2013

Video-rate Scanning Confocal Microscopy and Microendoscopy
14:10

Video-rate Scanning Confocal Microscopy and Microendoscopy

Published on: October 20, 2011

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
13:49

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Area of Science:

  • Gastroenterology and Hepatology
  • Medical Imaging
  • Oncology

Background:

  • Preoperative diagnosis of biliary neoplasms has low sensitivity, hindering effective treatment.
  • Existing diagnostic methods for biliary strictures lack sufficient resolution for definitive diagnosis.
  • Minimally invasive imaging techniques are needed to improve in vivo characterization of biliary lesions.

Purpose of the Study:

  • To evaluate the efficacy of probe-based confocal laser endomicroscopy (pCLE) for in vivo diagnosis of biliary neoplasms.
  • To assess the potential of miniaturized confocal miniprobes for use within cholangioscopes.
  • To determine the utility of pCLE in differentiating biliary and pancreatic strictures.

Main Methods:

  • Development and miniaturization of confocal miniprobes for use via cholangioscope instrumentation channels.
  • Application of probe-based confocal laser endomicroscopy for in vivo microscopic imaging of biliary strictures.
  • Analysis of imaging data to differentiate between neoplastic and non-neoplastic biliary lesions.

Main Results:

  • Probe-based confocal laser endomicroscopy enables in vivo microscopic imaging within the biliary system.
  • Miniaturized confocal miniprobes can be advanced through the working channel of cholangioscopes.
  • Preliminary data suggest pCLE is a promising tool for differentiating biliary and pancreatic strictures.

Conclusions:

  • Probe-based confocal laser endomicroscopy represents a novel and promising imaging modality for the diagnosis of biliary neoplasms.
  • The technology facilitates in vivo microscopic evaluation, potentially improving diagnostic accuracy for biliary and pancreatic strictures.
  • Further large-scale, multicenter studies are required to establish the definitive clinical significance of this advanced imaging technique.