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Updated: Jun 18, 2026

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using ¹⁸F-FDG PET

Published on: April 28, 2013

Bone disease after renal transplantation.

Hartmut H Malluche¹, Marie-Claude Monier-Faugere, Johann Herberth

¹Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, UK Medical Center, 800 Rose Street, Lexington, KY 40508, USA. hhmall@uky.edu

Nature Reviews. Nephrology

|November 18, 2009

Summary

Renal transplantation improves survival but can lead to bone loss and fractures due to pre-existing conditions and immunosuppression. Addressing low bone turnover is crucial for preventing fractures and cardiovascular disease post-transplant.

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Area of Science:

Nephrology
Endocrinology
Orthopedics

Background:

Renal transplantation has improved patient and graft survival.
Bone loss, fractures, and cardiovascular disease remain significant clinical challenges post-transplantation.
Factors contributing to bone loss include renal osteodystrophy, immunosuppressive drugs, and impaired renal function.

Purpose of the Study:

To review changes in bone histology and mineral metabolism after renal transplantation.
To discuss the impact of these changes on clinical outcomes like fractures and cardiovascular calcifications.
To evaluate therapeutic strategies for managing bone disease in renal transplant recipients.

Main Methods:

Review of current literature on bone disease following renal transplantation.
Analysis of histological findings in bone biopsies.
Examination of associations between bone parameters and clinical outcomes.

Main Results:

Renal transplant recipients often experience significant bone loss with decreased bone turnover and defective mineralization.
Low bone volume and low bone turnover are linked to cardiovascular calcifications.
These bone abnormalities present challenges for medical therapy and highlight the need for pre-transplant intervention.

Conclusions:

Bone loss and altered mineral metabolism are common after renal transplantation.
Preventing low bone turnover is critical for reducing fracture risk and cardiovascular complications.
Therapeutic approaches should consider the specific bone histology observed in these patients.